ISSB Regulation: Global Sustainability Standards Framework
Guide covering ISSB regulation from the foundation standards to country by country implementation, practical compliance steps and regulatory impact.
I conducted research across 160 companies in the biotechnology industry to understand their overall performance in Sustainability disclosure. The research started by understanding the ESG ratings of all companies from this industry and then did a deep dive into who the market views as the strongest sustainability players.
How does Biotechnology align with the GICS coding:
This sub‑industry classification captures companies whose principal business activity involves the research, development, and commercialization of biologically derived products, including therapeutics, diagnostics, genetic engineering, and cell and gene therapies.
The full list of companies that were included in this research is at the bottom of this article. The regional breakdown of companies assessed is shown below:
Germany: 2
Denmark: 3
United Kingdom: 5
Netherlands: 5
United States: 145
Ratings Performance: I looked at their ESG performance data from ESG ratings frameworks: such as ISS (Institutional Shareholder Services), CDP (Carbon Disclosure Project), MSCI, and Sustainalytics.I also looked at their stock price trend for the last year.
Rating Agency Summary:
ISS: Recursion Pharmaceuticals was also the highest scoring ISS company scoring a B and PRIME Status. They were the only company to get a B on ISS from the group. C+ was the most common score with 66 companies achieving that score. Roughly half of the companies on the list were ISS PRIME at 74 of 160 companies. PRIME was awarded for companies that achieved a C+ or higher.
CDP: The only company from the list who had a CDP score was Abbvie Inc who had a B in both CDP Climate Change and CDP Forests. Our research did not reveal CDP scores for the other companies.
MSCI: Only 1 company, Gilead Science Inc, was able to achieve an AAA. The rest of the companies fell between AA to B with the BB having the highest number of companies at 56 of 160.
Sustainalytics: Sustainalytics, where a lower score is better, the best performing company was Recursion Pharmaceuticals with a 17.6. The spread of performance was 17.6 to 41.3 with an average of 31.1.
In terms of growth rate, x40 companies were viewed as fast growing which we defined as a 10% or higher rise in stock price over the last 12 months. Within this group ISS and Sustainalytics were lower overall. For ISS, none of the fastest growing companies were able to achieve over a C+ grade and for Sustainaltytics the best score was Gilead Science. MSCI ratings were roughly aligned with the fast growing sub-group and the wider industry.
Finally, to start deeper company research I looked into the companies with the highest ratings across all three of the major agencies. For MSCI this was an A or above. For Sustainalytics a score of 26 or under and for ISS a C+ and PRIME score. This created a list of 12 companies who I conducted deeper research on. Those 12 companies are listed below:
ABBVIE INC.: Only CDP responder from the group. A stand- alone 54 page ESG Action Report is published and extensive policy disclosure on their website.
ALNYLAM PHARMACEUTICALS, INC.: Publishes a 94 page Corporate Responsibility Report. Significant comms on Patient Access.
AMGEN INC.: A 26 page Sustainability Highlights report was published. Also significant comms around Access to Healthcare.
ARGENX SE: CSRD aligned Annual Report with extensive communication across topics. Discussion on compliance and how they interact with the healthcare community.
BAVARIAN NORDIC A/S: CSRD aligned Annual Report.S4, Consumers and End Users heavily considered.
BIOGEN INC.: Published a 76 page Corporate Social Responsibility Report. SASB Index included in disclosure.
EXACT SCIENCES CORPORATION: 75 page Responsible Business Report was published. Also publish SASB and TCFD reports and a Corporate Impact webpage.
GENMAB A/S: CSRD Aligned Annual Report. Statements around Patient Advocacy.
GILEAD SCIENCES, INC.: 83 page Responsible Business and Impact Report. Key aim to Advance Access and Health Equity.
Lyell Immunopharma Inc: Has a 2023 ESG report but nothing for 2024. (As of 30 July 2025). 2023 Report is 19 pages.
MODERNA, INC.: Has a 2023 ESG Report but nothing for 2024. (As of 30 July 2025. 2023 Report is 61 pages long. They have extensive policies and statements on key issues within Sustainability topics.
REGENERON PHARMACEUTICALS, INC.: Published a 71 page 2024 report. They also do an additional Data Summary and a Materiality Assessment Statement.
I provide screenshots and examples below.
Immediately on their website the push positive Societal Impact and related disclosure
Extensive policies
Alnylam Pharmaceuticals: Specific statements on Patient Access
Amgen:
Argenx: Communicated management structure around ESG areas
Bavarian Nordic A/S: S4 IRO Table
Biogen: SASB Aligned disclosure
Exact Sciences: Statement from CEO around impact
Genmab:
Gilead Sciences
Moderna: Statements and Policies
Regeneron:
Want to streamline your ESG Disclosure? Gen in touch at solutions@nossadata.com to learn how we help the world's largest companies with all aspects of ESG.
Companies included in raw research:
IONIS PHARMACEUTICALS, INC.
4D Molecular Therapeutics Inc
89Bio Inc
ABBVIE INC.
ACADIA PHARMACEUTICALS INC.
ADMA BIOLOGICS, INC.
Agios Pharmaceuticals Inc
Akero Therapeutics Inc
Aldeyra Therapeutics Inc
Alector Inc
Allogene Therapeutics Inc
ALNYLAM PHARMACEUTICALS, INC.
ALTIMMUNE, INC.
ALX Oncology Holdings Inc
AMGEN INC.
AMICUS THERAPEUTICS, INC.
AnaptysBio Inc
Anavex Life Sciences Corp
Annexon Inc
APELLIS PHARMACEUTICALS, INC.
Arbutus Biopharma Corp
Arcellx Inc
Arcturus Therapeutics Holdings Inc
ARCUS BIOSCIENCES, INC.
Arcutis Biotherapeutics Inc
Ardelyx Inc
argenx SE
Arrivent Biopharma Inc
ARROWHEAD PHARMACEUTICALS, INC.
Astria Therapeutics Inc
Avacta Group PLC
Avidity Biosciences Inc
BAVARIAN NORDIC A/S
Beam Therapeutics Inc
BIOCRYST PHARMACEUTICALS, INC.
BIOGEN INC.
Biohaven Ltd
BIOMARIN PHARMACEUTICAL INC.
Biomea Fusion Inc
BLUEPRINT MEDICINES CORPORATION
BRIDGEBIO PHARMA, INC.
Cabaletta Bio Inc
Capricor Therapeutics Inc
CARGO Therapeutics Inc
CATALYST PHARMACEUTICALS, INC.
CELLDEX THERAPEUTICS, INC.
CG Oncology Inc
Cogent Biosciences Inc
COHERUS ONCOLOGY, INC.
Crinetics Pharmaceuticals Inc
Cullinan Therapeutics Inc
CureVac N.V.
CYTOKINETICS, INCORPORATED
Day One Biopharmaceuticals Inc
Denali Therapeutics Inc
Dianthus Therapeutics Inc
Disc Medicine Inc
DYNAVAX TECHNOLOGIES CORPORATION
Dyne Therapeutics Inc
EDITAS MEDICINE, INC.
Enanta Pharmaceuticals Inc
Entrada Therapeutics Inc
Erasca Inc
EXACT SCIENCES CORPORATION
EXELIXIS, INC.
FATE THERAPEUTICS, INC.
Formycon AG
GENMAB A/S
GENUS PLC
GERON CORPORATION
GILEAD SCIENCES, INC.
Grail Inc
HALOZYME THERAPEUTICS, INC.
HERON THERAPEUTICS, INC.
Humacyte Inc
IDEAYA Biosciences Inc
IGM Biosciences Inc
Immunitybio Inc
Immunome Inc
Immunovant Inc
INCYTE CORPORATION
INSMED INCORPORATED
INTELLIA THERAPEUTICS, INC.
IRONWOOD PHARMACEUTICALS, INC.
Iteos Therapeutics Inc
Jade Biosciences Inc
Janux Therapeutics Inc
Keros Therapeutics Inc
Kiniksa Pharmaceuticals International PLC
Korro Bio Inc
Krystal Biotech Inc
Kura Oncology Inc
Kymera Therapeutics Inc
Legend Biotech Corp
Lyell Immunopharma Inc
MacroGenics Inc
MADRIGAL PHARMACEUTICALS, INC.
MANNKIND CORPORATION
MeiraGTx Holdings plc
Merus NV
Metsera Inc
MIMEDX GROUP, INC.
MIRUM PHARMACEUTICALS, INC.
MODERNA, INC.
Monte Rosa Therapeutics Inc
MYRIAD GENETICS, INC.
NATERA, INC.
NEUROCRINE BIOSCIENCES, INC.
NewAmsterdam Pharma Company NV
NOVAVAX, INC.
Nurix Therapeutics Inc
Ocugen Inc
Olema Pharmaceuticals Inc
Oric Pharmaceuticals Inc
Oxford Biomedica PLC
Pharming Group N.V.
Praxis Precision Medicines Inc
Prime Medicine Inc
Protagonist Therapeutics Inc
PTC THERAPEUTICS, INC.
PureTech Health PLC
RAPT Therapeutics Inc
Recursion Pharmaceuticals Inc
REGENERON PHARMACEUTICALS, INC.
Regenxbio Inc
Relay Therapeutics Inc
Replimune Group Inc
Revolution Medicines Inc
Rhythm Pharmaceuticals Inc
ROCKET PHARMACEUTICALS, INC.
Roivant Sciences Ltd
SAGE THERAPEUTICS, INC.
Sana Biotechnology Inc
SAREPTA THERAPEUTICS, INC.
SAVARA INC.
Scholar Rock Holding Corp
SERES THERAPEUTICS, INC.
Soleno Therapeutics Inc
Spyre Therapeutics Inc
Stoke Therapeutics Inc
Syndax Pharmaceuticals Inc
Tango Therapeutics Inc
Tourmaline Bio Inc
TRAVERE THERAPEUTICS, INC.
Tyra Biosciences Inc
Ultragenyx Pharmaceutical Inc
Uniqure NV
UNITED THERAPEUTICS CORPORATION
Vaxcyte Inc
Vera Therapeutics Inc
VERICEL CORPORATION
VERTEX PHARMACEUTICALS INCORPORATED
Verve Therapeutics Inc
Viking Therapeutics Inc
Vir Biotechnology Inc
Viridian Therapeutics Inc
Xencor Inc
Y-mAbs Therapeutics Inc
Zealand Pharma A/S
Zymeworks Inc